| An Overview of DNA Nanotechnology for Detecting Cell-Free Tumor Markers |
| Paper ID : 1131-ICEEM2023 (R1) |
| Authors |
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Sara Sami Soliman *1, Prof. Fathi Abd EL-Samie2, said abdel atty3, Abeer Eshra4, wael badawy5 1Department of Electronics and Electrical communications Engineering, Faculty of Electronic Engineering, Menoufia University, Menouf, Egypt 2Department of Electronics and Electrical communications Engineering, Faculty of Electronic Engineering, Menoufia University, Menouf, Egypt 3dept. of electronics and electrical communications Faculty of electronic engineering Menoufia University Menouf, Egypt 4Department of Computer Science and Engineering, Faculty of Electronic Engineering, Menoufia University, Menouf, Egypt 5School of Physics, Engineering and Computer Science University of Hertfordshire Hosted by GAF United Kingdom |
| Abstract |
| Advancements in DNA nanotechnology have led to exciting new ways for the detection of cell-free tumor biomarkers, revolutionizing cancer diagnostics. This article presents a comprehensive overview of recent developments in the field, discussing the significance of liquid biopsies, DNA nanomachines, and DNA logic circuits in early cancer detection. Liquid biopsies, offering minimally invasive testing, hold potential for capturing tumor-specific components like circulating tumor cells, cell-free DNA, and exosomes. DNA nanomachines, advanced molecular devices, exploit the programmability of DNA sequences for the ultrasensitive and specific detection of these markers. DNA logic circuits are like mini computers made of DNA that can help with precise cancer detection. Scientists are also working on solving challenges like low marker concentrations and interference are addressed through microfluidic integration, nanomaterial amplification, and indirect signal detection. Despite advances, multiplex detection remains a challenge. In conclusion, DNA nanotechnology bears immense promise for cancer diagnostics, advocating personalized treatment and improving patient outcomes. Continued research could redefine how we find and treat tumor, leading to better outcomes for patients. |
| Keywords |
| Cancer, DNA nanotechnology, Tumor Markers, TME, Cell-Free, CTCs, EVs, ctDNA. |
| Status: Accepted |